Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation (ROCKET AF)

Further information: Antiarrhythmic Drugs (see p2085) from Cardiovascular Medicine, 3rd Edn*

Investigators conducted the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial to find an anticoagulant that is more manageable than warfarin for the prevention of stroke in patients with atrial fibrillation [1]. Warfarin, considered the standard treatment for atrial fibrillation, has many drawbacks and limitations, and numerous efforts …

Rivaroxaban in Patients with Acute Coronary Syndrome (ATLAS ACS2-TIMI 51)

Further information: Medical Treatment of Unstable Angina, Acute Non–ST-Elevation Myocardial Infarction, and Coronary Artery Spasm (see p937) from Cardiovascular Medicine, 3rd Edn*

Investigators conducted the Anti-Xa Therapy to Lower Cardiovascular Events in Addition to Standard Therapy in Subjects with Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 51 Trial (ATLAS ACS 2-TIMI 51) in order to find a treatment that will prevent recurrent cardiovascular events in patients who have had an acute coronary syndrome (termed unstable angina) […

Non-Culprit Coronary Artery Percutaneous Coronary Intervention During Acute ST-Segment Elevation Myocardial Infarction

Further information: Treatment of Acute ST-Elevation Myocardial Infarction (see p963) and Percutaneous Coronary Intervention for Acute Myocardial Infarction (see p1021) from Cardiovascular Medicine, 3rd Edn*

The wisdom of discouraging the performance of percutaneous coronary intervention (PCI) in non-infarct related arteries (non-IRA) concurrently with primary PCI was evaluated by investigators in the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial [1]. Guidelines from the European Society of Cardiology (ESC) and the …

Apixaban versus Warfarin in Patients with Atrial Fibrillation (ARISTOTLE)

Further information: Antiarrhythmic Drugs (see p2085) from Cardiovascular Medicine, 3rd Edn*

On March 30, 2011, a summary of the published results of the Apixaban Versus Acetylsalicylic Acid (ASA) to Prevent Stroke in Atrial Fibrillation Patients Who Have Failed or are Unsuitable for Vitamin K Antagonist Treatment (AVERROES) trial [1] was published on this website [2]. As the trial progressed, data …

Early Versus Later Rhythm Analysis in Patients with Out-of-Hospital Cardiac Arrest (ROC PRIMED trial)

Further information: Antiarrhythmic Drugs (see p2085) and The Implantable Cardioverter-Defibrillator (see p2119) from Cardiovascular Medicine, 3rd Edn*

According to an Editorial [1] written on two articles in the September 1, 2011 issue of The New England Journal of Medicine, the rate of survival for individuals having an out-of-hospital cardiac arrest has not improved in 30 years. The …

Adipocyte Fatty Acid Binding Protein in Atherosclerotic Plaques is Associated with Local Vulnerability and is Predictive for the Occurrence of Adverse CV Events

Further information: Atherosclerotic Vulnerable Plaques: Pathophysiology, Detection, and Treatment (see p621) and Biomarkers of Inflammation as Surrogate Markers in Detection of Vulnerable Plaques and Vulnerable Patients (see p641) from Cardiovascular Medicine, 3rd Edn*

An inflammatory disease of the arteries, atherosclerosis, leads to myocardial infarction (MI) and stroke, and researchers have long recognized the need to impede the formation and growth of atherosclerotic plaques before they rupture. Biomarkers that predict the progression of the disease have been identified, …

Cardiovascular Hospitalizations and Mortality Among Recipients of Hematopoietic Stem Cell Transplantation

Further information: Stem Cell Therapy for Cardiac Diseases (see p2745) from Cardiovascular Medicine, 3rd Edn*

Results reported here were of a retrospective cohort study that was conducted by investigators to compare the incidence of cardiovascular-related hospitalization and death in patients treated for cancer by hematopoietic stem cell transplantation (HSCT) with the general population [1]. The cohort included 1491 patients who had survived two-years after HSCT with no recurrent cancer, and …

Intracoronary Autologous Mononucleated Bone Marrow Cell Infusion for Acute Myocardial Infarction: Results of the Randomized Multicenter BONAMI trial

Further information: Stem Cell Therapy for Cardiac Diseases (see p2745) from Cardiovascular Medicine, 3rd Edn*

The Bone Marrow in Acute Myocardial Infarction (BONAMI) trial was conducted between December 2004 and April 2009, and the results of the study are reported in an issue of the European Heart Journal [1]. Results of earlier studies have shown that injection of autologous bone marrow cells (BMCs) in patients after acute myocardial infarction (AMI) led to improved cardiac …

Influenza Vaccination Reduces CV Events in Patients with ACS

Further information: Atherosclerosis: Pathogenesis, Morphology, and Risk Factors (see p1593) from Cardiovascular Medicine, 3rd Edn*

Although the role of infection and atherosclerosis has been studied for many years, and infectious organisms have been scrutinized regarding their involvement in the pathogenesis of atherosclerosis, trials using antibiotic therapy have not been conclusive in showing a clinical benefit. The investigators of the trial results reported here conducted the study to evaluate the effects of the influence vaccine on cardiovascular outcomes in acute coronary syndrome (ACS) patients […

Stents vs Bypass Surgery for Left Main CAD (PRECOMBAT)

Further information: Coronary Artery Bypass Surgery and Percutaneous Coronary Revascularization: Impact on Morbidity and Mortality in Patients with Coronary Artery Disease (see p1073) from Cardiovascular Medicine, 3rd Edn*

A randomized clinical trial has been needed for a decade to help determine whether coronary artery bypass surgery (CABG) or percutaneous coronary intervention (PCI) yields better outcomes in patients with unprotected left main coronary artery disease. During this time, concerns have centered around the fact that of the two procedures, angioplasty is less invasive and has a shorter recovery time, …

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